Semax 10mg

Semax — Synthetic ACTH(4-10) Analog Research Peptide

Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment of adrenocorticotropic hormone, modified with a Pro-Gly-Pro C-terminal extension that confers resistance to enzymatic degradation. Developed in Russia for cognitive and neuroprotective research, Semax has been the subject of over 100 peer-reviewed preclinical studies examining its action on neurotrophic signaling and ischemic neuroprotection.

Mechanism of Action

Preclinical research shows Semax upregulates BDNF and nerve growth factor (NGF) in hippocampal and cortical tissue, modulates dopaminergic and serotonergic neurotransmission, and acts on the melanocortin receptor system without engaging the corticosteroid axis. Studies in rodent ischemia models have characterized its effect on infarct volume, oxidative stress markers, and post-ischemic recovery of motor function. Its glutamatergic modulation is hypothesized to underlie observed effects on attention and working memory in animal cognition paradigms.

Research Applications

• Cerebral ischemia and stroke-recovery models
• BDNF and NGF expression research
• Cognitive performance and attention studies
• Neuroprotection in oxidative-stress paradigms
• Melanocortin receptor pathway investigations

Product Specifications

• Quantity: 10mg per vial
• Purity: ≥99% (HPLC verified)
• Molecular Formula: C₃₇H₅₁N₉O₁₀S
• Molecular Weight: 813.94 g/mol
• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: Third-party lab tested, COA available on request

For research purposes only. Not for human or veterinary use.