⁠MOTS-C

Description

MOTS-c — Mitochondrial-Derived Metabolic Peptide

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA region, representing one of the first characterized mitochondrial-derived peptides. Its discovery changed how researchers think about the mitochondrial genome: rather than a purely energetic organelle, the mitochondrion is now understood to issue signaling peptides that coordinate whole-body metabolism.

Mechanism of Action

MOTS-c translocates to the nucleus under metabolic stress and modulates nuclear gene expression governing glucose uptake, fatty acid oxidation, and the integrated stress response. It activates the AMPK energy-sensing pathway, enhances GLUT4-mediated glucose uptake in skeletal muscle, and influences folate cycle intermediates. Preclinical studies document improved insulin sensitivity, resistance to diet-induced obesity, and enhanced exercise capacity in rodent models treated with exogenous MOTS-c.

Research Applications

• AMPK pathway and cellular energy sensing studies
• Skeletal muscle glucose uptake research
• Insulin sensitivity and type-2 diabetes models
• Exercise capacity and mitochondrial biogenesis investigations
• Age-related metabolic decline research
• Mitochondrial-nuclear retrograde signaling studies

Product Specifications

• Quantity: 10mg per vial
• Purity: ≥98% (HPLC verified)
• Molecular Formula: C₈₁H₁₃₅N₂₁O₂₂S₂
• Molecular Weight: 1820.2 g/mol
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: Third-party lab tested, COA available on Portal
• Actual Tested Value: 10.66 mg

For research purposes only. Not for human or veterinary use.