Selank

Description

Selank: Tuftsin-Derived Heptapeptide Research Peptide

Selank is a synthetic heptapeptide derived from the immunomodulator tuftsin, originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Its Pro-Gly-Pro C-terminus extends in-vivo half-life and enables stable intranasal bioavailability in preclinical models, which has made it a workhorse of cognitive and stress-response peptide research for more than two decades.

Mechanism of Action

Preclinical studies show Selank modulates expression of brain-derived neurotrophic factor (BDNF), influences monoamine neurotransmitter tone (serotonin, dopamine, norepinephrine), and produces measurable shifts in hippocampal gene expression related to neuroplasticity. Unlike benzodiazepines, Selank does not directly bind GABA-A receptors; it modulates GABAergic activity indirectly through enkephalin and monoaminergic pathways, which is the dominant hypothesis for its non-sedating stress-response profile in animal models.

Research Applications

• Anxiety-related behavior in rodent models
• Cognitive performance and attention investigations
• BDNF expression and neuroplasticity studies
• Stress-axis modulation research
• Enkephalin and monoamine system interaction studies

Product Specifications

• Quantity: 10mg per vial
• Purity: ≥99% (HPLC verified)
• Molecular Formula: C₃₃H₅₇N₁₁O₉
• Molecular Weight: 751.88 g/mol
• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Actual Tested Value: 10.4 mg

For research purposes only. Not for human or veterinary use.