KPV 10mg

KPV — C-Terminal α-MSH Tripeptide

KPV is the C-terminal tripeptide of α-melanocyte-stimulating hormone, composed of lysine-proline-valine. Despite its minimal size, KPV retains the anti-inflammatory activity of the parent hormone while shedding the pigmentation and appetite-modulating effects that are driven by other regions of α-MSH. This separation of activities has made KPV a precision research tool for studying inflammation pathways in isolation.

Mechanism of Action

KPV suppresses NF-κB nuclear translocation and downstream pro-inflammatory cytokine expression, particularly TNF-α, IL-1β, and IL-6. Research has documented stabilization of mast cells, reduction in mast cell degranulation, and improvements in intestinal epithelial barrier integrity. The peptide appears to enter cells without requiring melanocortin receptor binding, positioning it as mechanistically distinct from the receptor-mediated actions of full-length α-MSH. Its compact size supports oral and topical administration studies.

Research Applications

• Intestinal inflammation and IBD preclinical models
• NF-κB pathway and cytokine suppression studies
• Mast cell stabilization research
• Epithelial barrier function and tight-junction integrity
• Dermatological inflammation investigations
• Oral bioavailability and peptide absorption research

Product Specifications

• Quantity: 10mg per vial
• Purity: ≥99% (HPLC verified)
• Molecular Formula: C₂₂H₃₂N₆O₄
• Molecular Weight: 444.52 g/mol
• Sequence: Lys-Pro-Val (H-KPV-OH)
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: Third-party lab tested, COA available on Portal
• Actual Tested Value: 9.48mg

• For research purposes only. Not for human or veterinary use.