AHK-Cu (RAW) 1g

AHK-Cu (RAW) 1g — Alanyl-L-Histidyl-L-Lysine Copper-Binding Tripeptide

AHK-Cu in its raw lyophilized form is the unloaded tripeptide Ala-His-Lys, supplied for bulk research applications where the user controls copper-loading stoichiometry at reconstitution. AHK is a structural analog of GHK with the N-terminal glycine substituted by alanine, which alters the copper-binding pocket geometry and produces a distinct profile in hair-follicle and skin-research models.

Mechanism of Action

AHK forms a coordination complex with divalent copper analogous to GHK-Cu but with subtly different binding kinetics and tissue distribution. Preclinical research has characterized AHK-Cu’s particular affinity for hair-follicle dermal-papilla cells, where it has been investigated for its action on vascular endothelial growth factor (VEGF) signaling and follicular angiogenesis. Comparative studies against GHK-Cu and biotinyl-GHK frequently use AHK-Cu as a reference peptide for studies isolating copper-coordination effects from sequence-specific receptor binding.

Research Applications

• Hair-follicle dermal-papilla research
• VEGF signaling and angiogenesis studies
• Copper-binding peptide comparative pharmacology
• Topical cosmetic peptide formulation research
• Tissue-remodeling enzyme expression investigations

Product Specifications

• Quantity: 1g (1000mg) per vial, RAW (no copper-loading)
• Purity: ≥99% (HPLC verified)
• Molecular Formula: C₁₅H₂₆N₆O₄ (base peptide, pre-Cu)
• Molecular Weight: 354.41 g/mol (base peptide)
• Sequence: Ala-His-Lys
• Form: Lyophilized powder, raw tripeptide
• Storage: Refrigerate after reconstitution
• Testing: Third-party lab tested, COA available on request

For research purposes only. Not for human or veterinary use.