GHK-Cu (RAW) 1g

GHK-Cu (RAW) 1g — Glycyl-L-Histidyl-L-Lysine Copper-Binding Tripeptide

GHK-Cu in its raw lyophilized form is the unloaded tripeptide Gly-His-Lys, supplied for bulk research applications where the user controls copper-loading stoichiometry at the point of use. Originally isolated from human plasma by Loren Pickart in 1973, GHK-Cu has been characterized in more than four decades of research on tissue remodeling, matrix biology, and gene-expression modulation.

Mechanism of Action

GHK forms a high-affinity complex with divalent copper, and the resulting GHK-Cu(II) complex shuttles physiological copper into fibroblasts where it influences collagen, elastin, and glycosaminoglycan synthesis. Preclinical studies show GHK-Cu modulates expression of over 4,000 human genes, including upregulation of antioxidant defense systems (SOD, catalase) and tissue-remodeling enzymes (MMP-2, TIMP). Its activity profile spans wound-edge keratinocytes, hair-follicle dermal-papilla cells, and aging fibroblasts, which has made it a workhorse of regenerative-dermatology research.

Research Applications

• Matrix-remodeling and tissue-regeneration studies
• Hair-follicle dermal-papilla research
• Fibroblast gene-expression and collagen-synthesis investigations
• Antioxidant defense system upregulation
• Copper-binding peptide pharmacology

Product Specifications

• Quantity: 1g (1000mg) per vial, RAW (no copper-loading)
• Purity: ≥99% (HPLC verified)
• Molecular Formula: C₁₄H₂₄N₆O₄ (base peptide, pre-Cu)
• Molecular Weight: 340.39 g/mol (base peptide)
• Sequence: Gly-His-Lys
• Form: Lyophilized powder, raw tripeptide
• Storage: Refrigerate after reconstitution
• Testing: Third-party lab tested, COA available on request

For research purposes only. Not for human or veterinary use.