Snap 8 10mg

SNAP-8 (Acetyl Octapeptide-3) — SNARE-Modulating Cosmetic Research Peptide

SNAP-8 is a synthetic acetylated octapeptide that mimics the N-terminal end of SNAP-25, a component of the SNARE complex responsible for vesicle docking and neurotransmitter release at presynaptic terminals. Developed as a topically active research peptide modeled on SNARE-complex disruption mechanics first characterized with botulinum toxin, SNAP-8 has been investigated for its capacity to attenuate acetylcholine-mediated muscle contraction at neuromuscular junctions in cell-culture and ex-vivo models.

Mechanism of Action

Preclinical research shows SNAP-8 competes with native SNAP-25 for incorporation into the SNARE complex, destabilizing assembly of the syntaxin-SNAP-25-VAMP ternary structure required for vesicle fusion. By interfering with vesicle docking at the presynaptic membrane, SNAP-8 modulates acetylcholine release in dose-dependent fashion. Comparative studies have characterized its activity profile relative to argireline (acetyl hexapeptide-3), with SNAP-8 typically showing extended peptide length and altered binding kinetics.

Research Applications

• SNARE-complex assembly and disruption studies
• Acetylcholine release modulation in neuromuscular preparations
• Topical cosmetic peptide formulation research
• Comparative SNAP-25-mimetic peptide studies
• Skin barrier permeability investigations

Product Specifications

• Quantity: 10mg per vial
• Purity: ≥98% (HPLC verified)
• Molecular Formula: C₃₇H₆₆N₁₄O₁₃S
• Molecular Weight: 894.0 g/mol
• Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: Third-party lab tested, COA available on request

For research purposes only. Not for human or veterinary use.