TB-500

Description

TB-500 — Thymosin Beta-4 Active Fragment

TB-500 is a synthetic 7-amino-acid fragment of Thymosin Beta-4 (Tβ4) corresponding to the actin-binding region of the parent protein. By isolating the bioactive core, TB-500 delivers the regeneration-associated activity of Tβ4 in a smaller, more readily synthesizable molecule, making it a workhorse peptide in soft-tissue and cardiovascular regeneration research.

Mechanism of Action

TB-500 binds monomeric G-actin through its conserved LKKTETQ motif, sequestering actin and influencing cytoskeletal dynamics during cell migration and matrix-remodeling research. Research has documented upregulation of laminin-5, increased endothelial progenitor cell mobilization, and accelerated reendothelialization after vascular injury. The fragment also interacts with paxillin and integrin-linked kinase pathways, which together support the formation of new capillaries and the organized remodeling of damaged extracellular matrix.

Research Applications

• Soft tissue and skeletal muscle regeneration studies
• Cardiovascular regeneration and post-infarct remodeling research
• Corneal and epithelial barrier-recovery investigations
• Endothelial progenitor cell mobilization studies
• Hair follicle regeneration and dermal biology
• Angiogenesis in ischemic tissue models

Product Specifications

• Quantity: 10mg per vial
• Purity: ≥99% (HPLC verified)
• Sequence: Ac-LKKTETQ-OH (active Tβ4 fragment)
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: Third-party lab tested, COA available on Portal
• Actual Tested Value: 9.81 mg

For research purposes only. Not for human or veterinary use.